Z-Lab, December 2018.  Down the tree:  Roberto Zoncu, Oliver Davis, Ashley Thelen, Regina Shin, Joseph Paul, Ben Croze, Rose Citron, Robin Stipp, Rosalie Lawrence, Chun-Yan Lim, Subhrajit Banerjee.  On the tree:  Justin Zhang, Ann Deng, Jiayi Luo, Nikki Cheung.

Z-Lab, December 2018. Down the tree: Roberto Zoncu, Oliver Davis, Ashley Thelen, Regina Shin, Joseph Paul, Ben Croze, Rose Citron, Robin Stipp, Rosalie Lawrence, Chun-Yan Lim, Subhrajit Banerjee. On the tree: Justin Zhang, Ann Deng, Jiayi Luo, Nikki Cheung.

Roberto Zoncu (PI)

rzoncu@berkeley.edu

Roberto studied molecular biology at the University of Pisa, Italy, where he completed his undergraduate thesis on the mechanisms of asymmetric stem cell division during brain development

He then moved to Yale University to pursue a PhD in Cell Biology. Working in Pietro De Camilli’s laboratory, he used advanced microscopy and chemical genetic techniques to interrogate how a class of phospholipids known as phosphoinositides control endocytic vesicle traffic and maturation.

In 2008, he joined the laboratory of David Sabatini at the Whitehead Institute/MIT. There, he combined biochemical and microscopy-based assays to understand how lysosomes govern the signaling activity of the master growth regulator, mTORC1 kinase, and how these organelles generally function as a metabolic signaling centers.

In early 2014, Roberto became an Assistant Professor in the Biochemistry, Biophysics and Structural Biology division of the Molecular and Cell Biology Department at UC Berkeley. He was recently elected Pew Stewart-Scholar for Cancer Research.

 

Rosalie Lawrence (Graduate Student & NSF Fellow)

rosalielawrence@berkeley.edu

Rosalie grew up in Santa Cruz, CA and went to Swarthmore College where she majored in Biology, with minors in Chemistry and Environmental Studies, and competed with the swim team. She spent one year doing vaccine development research in Botswana prior to entered Berkeley's MCB program. She is interested in using biochemical and optical techniques to study growth signaling in mechanistic detail. In her spare time Rosalie loves being outdoors and exercising (especially when they go together), traveling, and cooking.

Ashley Thelen (Graduate Student & NSF Fellow)

athelen@berkeley.edu

Ashley received her Bachelor's degree from the University of Nebraska-Lincoln where she double majored in Biochemistry and Microbiology.  She worked with Professors Melanie Simpson and Joseph Barycki to investigate allosteric regulation of the metabolic enzyme UDP-glucose dehydrogenase.  Ashley joined the Zoncu Lab in 2015 and is interested in using chemical biology approaches to study nutrient sensing at the lysosome.  Outside of the lab, you can usually find her on the trails hiking or biking or in a coffee shop maximizing her daily caffeine intake. 

 

 

 

Oliver Davis (Graduate Student)

o.davis@berkeley.edu

A true east coast native, Oliver grew up in Rochester, NY and from there moved to Massachusetts to attend Amherst College. After graduating with a Bachelor’s in Chemistry, he spent several years as a research technician in Boston, working on HIV vaccine development at the Ragon Institute of MGH, MIT, and Harvard. In order to pursue advanced training in biochemistry and chemical biology, Oliver made the big move across the country to join the MCB graduate program here at Berkeley in 2014. In the Zoncu lab he is interested in investigating the mechanisms by which cells are able to sense their nutritional and metabolic states. Outside of the lab you can find Oliver enjoying the great outdoors, and rooting for the Red Sox!

 

Justin Zhang (Graduate Student)

zhangju@berkeley.edu

Justin grew up in Portland, OR and did not move far for undergraduate. He went to Oregon State University majoring in biochemistry and biophysics. Justin originally wanted to move to the east coast and spent a year after college working at the NIH in D.C. He ultimately decided to come back west and joined the Berkeley MCB program in 2015. In the Zoncu lab he is interested in understanding mechanisms by which lysosomes sense and transport nutrients. In his spare time, you can find Justin outdoors either running, hiking, or cycling. 

 

Joseph Paul (Graduate Student & NSF Fellow, jointly with Andy Dillin's lab)

jpaul3@berkeley.edu

Joseph earned his undergraduate degree in biology from East Carolina University where he developed tools for genome editing in plants and conducted research on the molecular mechanisms of neurodegeneration. He is now a joint student in the Zoncu and Dillin labs and is exploring how stress responses and metabolism are coordinated across different organelles and how organelle communication changes during aging. Outside of the lab he enjoys exploring the beautiful state of California and trying new food around the bay.    

  

 

Regina Shin (Postdoctoral Fellow)

hrshin@berkeley.edu

Regina_pic2017.jpg

Hijai Regina Shin was born and raised in France. She then moved to South Korea and received her Ph.D at Seoul National University. Her Ph.D thesis was on the epigenetic and transcriptional regulation of autophagy. Regina is now a postdoc at Roberto Zoncu’s lab. She is interested in nutrient sensing mechanisms by the lysosomes and their long-term effects in metabolism and health when challenged. Outside the lab, Regina enjoys spending time with her family and exploring the Bay area.

 

 

 

Ofer Moldavski (National Niemann-Pick Foundation Postdoctoral Fellow)

ofermo@berkeley.edu

Ofer (NOT Offer) is a post-doc originally from Israel. He completed his Ph.D. in Maya Schuldiner's lab at the Weizmann Institute, where he investigated cellular homeostasis through high-throughput screens in Yeast, focusing mainly on aggregates and protein quality control. Ofer is currently interested in the regulation of nutrient transport to and from the lysosome. He loves to play with his kids and to cook with his wife.

 

 

 

Chun-Yan Lim (American Heart Association Postdoctoral Fellow)

chunyan_lim@berkeley.edu

Originally from Malaysia, Chun-Yan received his Ph.D. in Biochemistry from National University of Singapore (NUS). Working in the Laboratory of Metabolic Medicine at the Singapore Bioimaging Consortium under the supervision of Weiping Han, he combined live-cell TIRF microscopy and biochemical techniques to investigate how Akt signaling modulates actin remodeling to facilitate insulin-stimulated GLUT4 exocytosis. In Dec 2015, he joined the Zoncu lab as a postdoc where he is interested in dissecting new signaling nodes that convey the metabolite information in and out of the lysosome. Outside of the lab, Chun-Yan enjoys traveling, exploring food from different countries, and spending times with his loved ones.

 

Subhrajit Banerjee (Postdoctoral Fellow)

banerjee18@berkeley.edu

Subhra_GRC2017.png

Subhra grew up in India, completing his Bachelors and Masters degree from the Calcutta University. He received his PhD from Patty Kane's lab at SUNY Upstate in Syracuse, where he worked on how phosphoinositide lipids regulate acidification of subcellular organelles. Subhra joined the Zoncu lab in September, 2018. He is interested in understanding the molecular basis of nutrient signal transduction from the lysosome. In his spare time, Subhra enjoys classical and rock music, poetry, cooking, and watching movies.

CitronPhoto.jpeg

Rose Citron (Postdoctoral Fellow)

yrcitron@berkeley.edu

Rose Citron grew up in Boston and moved to California after college. She completed her PhD at UCSF in the labs of Bo Huang and David Agard investigating the protein organization and self-assembly of centrosomal proteins in cells and through in vitro reconstitution. Rose joined the Zoncu lab to work on understanding the molecular mechanisms that drive and regulate mTORC1 activation on the lysosome. Rose enjoys being outside hiking and going to the symphony, ballet, and independent cinema.

Robin Stipp (Master student)

robin.stipp@googlemail.com

RobinStipp.jpg

Robin was born and raised in a small village in southern Germany. After completing his Bachelor Thesis dealing with the establishment of an in vitro pathway, he is currently enrolled as a master student of biochemistry at the university of Heidelberg. Robin joined the lab to investigate the nutrient sensing mechanism occuring in the lysosome. If not in the Lab he enjoys skiing, swordfighting and archery.

Ben Croze (Junior Specialist)

bcroze@berkeley.edu

Ben Crozw Picture.jpg

Ben is a Bay Area native from Lafayette, California. He attended the University of California, Davis where he studied Biochemical Engineering. In college, Ben did research on a variety of topics ranging from microbiology to sleep patterns to air pollution. After graduating in June 2017, he chose to stick with the UC system and is now a lab manager/junior specialist in the Zoncu lab at Cal! Ben is interested in keeping the lab running smoothly and in MCB research as it relates to drug discovery. In his spare time, Ben enjoys soccer, music of all sorts, being outdoors, trying out new coffee shops, and spending time with friends.

 

Ann Deng (Undergraduate)

adeng@berkeley.edu

Ann Picture

Ann grew up in the suburbs of Sacramento, California and is now an undergrad double majoring in Molecular and Cell Biology and Music. She is interested in using in vitro systems to study the regulation of nutrient signaling at the lysosome. In her spare time, she enjoys listening to different musics, dancing, and trying out new tea and coffee shops.

 

Lab Alumni

Brian castellano (postdoctoral scientist at genentech)

Currently postdoctoral scientist at Genentech

EMMA sydir (UNDERGRADUATE STUDENT)

Currently Ph.D. student in the Biophysics Program at Harvard Medical School

Marie Tofaute (master student, technical university of munich)

Currently Ph.D. student at the Max Planck Institute for Biochemistry

Yangxue Fu (master Student, UNIVERSITY OF heidelberg)

Currently Ph.D. student in Ivan Dikic s lab, University of Frankfurt

 

KELVIN CHO (UNDERGRADUATE STUDENT)

Currently Ph.D. student in Alice Ting lab, Stanford University

 

RONJA RAPPOLD (MASTER'S STUDENT, UNIVERSITY OF HEIDELBERG)

 

Marlies ludikhuize (master's student, utrecht university)

Currently a PhD student in the lab of Dr. Boudewijn Burgering, University of Utrecht

 

Christian bindesboll (visiting postdoctoral fellow, university of oslo)

 

Anna Thrun (master's student, freie university berlin)

Currently PhD student in the lab of Dr. Claudio Joazeiro, Heidelberg University

 

kasper kommeren (master's student, utrecht university)

 

BOB van EIJKEREN (master's student, utrecht university)

Currently PhD student in the lab of Dr. Eric Kalkhoven, University of Utrecht

 

Reini van der Welle(master's student, utrecht university)

Currently PhD student in the lab of Dr. Judith Klumpermann, University of Utrecht

 

Lab Time Lapse:

Z-Lab, October 2017.  First row:  Roberto Zoncu, Oliver Davis, Marie Tofaute, Chun-Yan Lim, Regina Shin, Jiayi Luo, Ben Croze, Ashley Thelen, Rosalie Lawrence, Ofer Moldavski.  Second row:  Yangxue Fu, Brian Castellano.  On the tree:  Kyle Tucker, Joseph Paul, Emma Sydir, Justin Zhang.

Z-Lab, October 2017. First row: Roberto Zoncu, Oliver Davis, Marie Tofaute, Chun-Yan Lim, Regina Shin, Jiayi Luo, Ben Croze, Ashley Thelen, Rosalie Lawrence, Ofer Moldavski. Second row: Yangxue Fu, Brian Castellano. On the tree: Kyle Tucker, Joseph Paul, Emma Sydir, Justin Zhang.

Z-Lab, March 2017: First row:  Kelvin Cho, Roberto Zoncu, Oliver Davis, Jiayi Luo, Chun-Yan Lim, Ann Deng, Ashley Thelen, Ofer Moldavski.  Second row:  Eric Schade.  On the tree:  Yangxue Fu, Brian Castellano, Ronja Rappold, Emma Sydir, Justin Zhang, Rosalie Lawrence.

Z-Lab, March 2017: First row: Kelvin Cho, Roberto Zoncu, Oliver Davis, Jiayi Luo, Chun-Yan Lim, Ann Deng, Ashley Thelen, Ofer Moldavski. Second row: Eric Schade. On the tree: Yangxue Fu, Brian Castellano, Ronja Rappold, Emma Sydir, Justin Zhang, Rosalie Lawrence.

Z-Lab, May 2016

Z-Lab, May 2016

Z-Lab, January 2016

Z-Lab, January 2016

Z-Lab, July 2015

Z-Lab, July 2015

Z-Lab, September 2014

Z-Lab, September 2014

Z-Lab, May 2014

Z-Lab, May 2014